Monday, April 30, 2012

Fellow Human Variants,

After the hysterical, insightful, and varied presentations on the last day of classes I was putting together some thoughts for the final paper. In my presentation I added a picture of my sister, Sarah, and me from when we were toddlers and compared it to how we are now. Just to jog your memory...

Sarah on left, me on right

     
Me on left, Sarah on right    



Sarah and I are 18 months apart, we have lived in the same house our entire lives, have the same parents, went to the same preschool, kindergarten, elementary, middle, and high school. Considering we share so much of our genes, and our environment are virtually identical, what makes us so different?

Thinking back so stories my parents used to tell, people thought we were twins! This may be partially due to the endless matching outfits my mother provided, but also the many traits we share. Today, however, people think I'm playing a practical joke when I tell them that Sarah is my biological sister.

In this class I've learned the roll that genes play in a person's phenotype, and even today I see many similarities between Sarah and I. Once friends get to know us together they often comment how we have the same laugh, the same mannerisms, same eyes, and lips.

Maybe Sarah is so different from me because of that 18 month age gap. Even though we are so close in age we were still in different grades in school, giving us different friend groups. I am very athletic, and Sarah was always very musical, just as Sarah was always very quiet and I was always very outgoing.

Even the smallest bit of change in environment can make a difference. Sarah and I turned out very different in some ways, just because of that small age gap.

BUT genes are also very important. During the presentations I heard a lot about environment that makes you, you. For me, that holds true but my genes also make me, me. Sarah's genes make her, her, but OUR genes make us so similar.

So the moral of my story is to not dismiss genes as an influential factor, because they are! The .1% difference in humans throughout the world make variation and they make you, you. 


Friday, April 27, 2012

A poem of relevance

Human Family

by Maya Angelou


I note the obvious differences
in the human family.
Some of us are serious,
some thrive on comedy.

Some declare their lives are lived
as true profundity,
and others claim they really live
the real reality.

The variety of our skin tones
can confuse, bemuse, delight,
brown and pink and beige and purple,
tan and blue and white.

I've sailed upon the seven seas
and stopped in every land,
I've seen the wonders of the world
not yet one common man.

I know ten thousand women
called Jane and Mary Jane,
but I've not seen any two
who really were the same.

Mirror twins are different
although their features jibe,
and lovers think quite different thoughts
while lying side by side.

We love and lose in China,
we weep on England's moors,
and laugh and moan in Guinea,
and thrive on Spanish shores.

We seek success in Finland,
are born and die in Maine.
In minor ways we differ,
in major we're the same.

I note the obvious differences
between each sort and type,
but we are more alike, my friends,
than we are unalike.

We are more alike, my friends,
than we are unalike.

We are more alike, my friends,
than we are unalike.

Overcoming Genophobia

Misha Angrist's article in the HuffPo captures some of the spirit of our course experiment.

"the rhetoric of fear does none of us any favors"

Thursday, April 26, 2012

Last day of class

Dear Human Variants,
You made me laugh and you made me cry today and I know that's not the point of our course, but it sure was lovely to be in that classroom this afternoon! It felt like the center of the universe for just one hour. Thank you all for opening up like that and for embracing this experience! I am completely inspired by you all.
Verklempt,
HD

Monday, April 23, 2012

What makes me, me

I was working on our upcoming group presentation and on answering the questions: what makes me human and what makes me, me?  For the most part, the things I ended up using to define myself had little to do with my genetics...or did they? 

I used aspects of my culture, my values, my appearance, and my past life experiences as classifications of my identity.  Apart from my appearance, what I think makes me me has a lot to do with external forces acting upon me instead of being genetically predetermined. 

But then again, we only know what a small portion of our DNA encodes for and even the things we do know could be affected by the unknown factors.  It is possible that the things I think have nothing to do with genetics may actually be intricately intertwined, or even predetermined by my genetics. 

Could your DNA encode for a propensity toward certain kinds of people and thus predetermine the friends you choose?  Could you be genetically inclined to live in a specific region therefore impacting the culture one is exposed to?  Does our biochemical make-up have a larger, albeit less direct, influence on what it takes for you to be you and for me to be me?  Maybe it is feasible that our genetics have already predetermined areas of our lives that we've attributed to being consequences of the environment. 

The reasoning behind all of this becomes pretty circular without more research and new discoveries.    

Saturday, April 21, 2012

My Humanity, My Identity. Part II: Universal Problems

Now that Part I has laid out our goals, let's tackle the questions we've raised one step at a time. We'll start with the one I think is more complicated, "What makes me human?" as I suspect my humanity will be more useful to answering questions about my identity than the reverse. It might be helpful when reading this series to not assume that I am explicitly stating any one point of view as fact immediately, but rather attempting to be thorough with different ways to conceptualize and analyze the issue at hand so that we can find the one we might consider the best. 

So when we ask a question like "What makes me human?", what do we take this to mean? For clarity's sake, let's phrase this for the moment as "What makes me a human?" as we do not seem to be using "human" here to describe us the same way we might use it to describe other things, e.g. "human skeleton" or "human folly."

We might approach and interpret the question this way: there are many things in the world which I can accurately identify as humans, but of course, there's only one me.  So "Ryan" is a particular thing, but "human" is a universal category that doesn't exist in any one thing. So what is it about the particular "Ryan" that makes it fit into the category "human"?  Well, it makes sense that whatever it is that makes me a human being should be the same thing(s) that makes all other human beings fit into this category.  We don't say things like "Holly is a human being, but not in the same sense that Jordan is."  We'd have trouble understanding what someone meant by such a statement, most likely.

So if we wanted to define what a human being is, we would probably refer to a property or set of properties defined by (let's say) scientific criteria attributable to all humans. Thus, we might restate our original question like so: "What are the properties of the particular 'Ryan' which make it a part of the category 'human being'?"

Now there have been lots of attempts to define "human being" and "humanity" with this and similar approaches. Rather than go through endless examples of this, let's discuss what needs to be true for this approach to actually work. We have asked ourselves, "What are the properties that classify individuals as humans?" For any definition or classification of human that uses this approach, we must be able to imagine absolutely no possibilities where:

a) something would be human without one such property, or
b) something would not be human despite the presence of all these properties.

It is important that we allow for hypothetical scenarios here, as they are what really show the limitations of any given definition. Let's take the scholastic definition of human as "rational animal." Given what we know about evolution, we should be able to easily imagine a new species of animal with Homo sapiens as its ancestor and the capacity for reason that we would not call "human." And so while "rational animal" may be a practical definition in that we could only use it to describe one thing that exists, it does not account for all possibilities. It would be like defining the genus Homo in terms of Homo sapiens because there is only one species within that genus that exists currently.

Speaking of evolution, this approach makes another very important assumption, namely, something either is human or is not. That doesn't seem to go in line with what we know, however.  I propose another thought experiment to demonstrate this:

Can we go back far enough in our evolutionary history to find a human whose mother is not human?

I think this would be extremely difficult and unlikely, even without the part that requires time travel. Evolutionary progress seems to be more of a continuum than a sequence of stages. Would our criteria allow us to draw that metaphorical line which creates such a distinct categorical separation? Even if we wanted to talk about this in strictly biological terms, we still run into the notorious species problem, which seems to me to be the exact same problem faced when defining any taxonomic or categorical term.

These difficulties should be extremely relevant to us, and it is important to bring them to light before going any further in this investigation.  For literally over two thousand years it was taken for granted that category terms had fixed boundaries and that any debate over these boundaries was not a sign of the insufficiency of this approach, but rather a matter to be settled with time. It was only in the mid-20th century that this idea came under serious questioning and attack in philosophy, anthropology, and cognitive science. Even though we often talk now of "gray areas," the idea that most things "either are or are not" any given universal term is still prevalent in the way we conceptualize, categorize, and organize the world we see around us.  We create definitions that are useful in most cases yet are full of exceptions.

So what can we do without these fixed boundaries, you ask? That's the subject for Part III!

Wednesday, April 18, 2012

Nature AND Nurture

For decades the nature vs. nurture debate went on, but with the field of genetics growing rapidly, we can agree that a person's "identity" is nature AND nurture. Once again, procrastinating, I stumbled across a blog written by Robery Klitzman, M.D., who discuses the role genetic testing plays. With recent advancements DNA testing has become relatively cheap and the amount of people getting these tests are skyrocketing. The question remains, does everyone know what to do with their results?

Those who are getting these tests need to know that they are not definitive, in terms of if this person was at a "higher risk" of a certain disease, it is not definite. Yes, some diseases it is 100% genetic, but for the vast majority they are not. With nature being your genes, and nurture being your environment, both play a role in what makes you, you.

Dr. Klitzman compares these results to the weather forecast. Sure, there is a chance it may rain, meteorologists have sufficient evidence that it will rain, but how many times have you flipped on the weather and they have predicted rain, but the storm never reached your specific area?

In my opinion, these tests are great. If you do have a higher chance of getting a certain disease it gives you the opportunity to do something about it. In terms of my results I am at a higher risk for Parkinson's Disease. 23andMe gives "what you can do" to lower your chance of developing the disease, drink coffee or tea, and stay active. Luckily I do both, but it still gives me the tools for early detection which may decrease the symptoms associated with this disease.

If your interested and want to read the article, I've posted the URL below
http://www.stumbleupon.com/su/4zhhdY/:avtbLD6s:DaCRfzA3/www.huffingtonpost.com/robert-klitzman-md/genetic-testing_b_1321901.html/